Clarogen

Clarogen may be available in the countries listed below.

Ingredient matches for Clarogen

Clarithromycin

Clarithromycin is reported as an ingredient of Clarogen in the following countries:

• Slovenia

International Drug Name Search

Monurol

In the US, Monurol (fosfomycin systemic) is a member of the drug class urinary anti-infectives and is used to treat Bladder Infection and Transurethral Prostatectomy.

US matches:

• Monurol

Ingredient matches for Monurol

Fosfomycin

Fosfomycin is reported as an ingredient of Monurol in the following countries:

• Turkey

Fosfomycin tromethamine (a derivative of Fosfomycin) is reported as an ingredient of Monurol in the following countries:

• Chile


• Greece


• Hong Kong


• Iceland


• Israel


• Malaysia


• Mexico


• Peru


• Spain


• United States

International Drug Name Search

Angiovan GMP

Angiovan GMP may be available in the countries listed below.

Ingredient matches for Angiovan GMP

Amlodipine

Amlodipine besilate (a derivative of Amlodipine) is reported as an ingredient of Angiovan GMP in the following countries:

• Venezuela

International Drug Name Search

Depo-Testosterone

testosterone cypionate

Dosage Form: injection, solution
Depo®-Testosterone

testosterone cypionate injection, USP    CIII

Depo-Testosterone Description

Depo-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone.

Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.

The chemical name for testosterone cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:

Depo-Testosterone Injection is available in two strengths, 100 mg/mL and 200 mg/mL testosterone cypionate.

Each mL of the 100 mg/mL solution contains:

    Testosterone cypionate................................................................................... 100 mg

    Benzyl benzoate .............................................................................................. 0.1 mL

    Cottonseed oil ................................................................................................ 736 mg

    Benzyl alcohol (as preservative) ..................................................................... 9.45 mg

Each mL of the 200 mg/mL solution contains:

    Testosterone cypionate .................................................................................. 200 mg

    Benzyl benzoate .............................................................................................. 0.2 mL

    Cottonseed oil ................................................................................................ 560 mg

    Benzyl alcohol (as preservative) ..................................................................... 9.45 mg

Depo-Testosterone - Clinical Pharmacology

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, testosterone cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.

The half-life of testosterone cypionate when injected intramuscularly is approximately eight days.

In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Depo-Testosterone

Depo-Testosterone Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.

2. Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Contraindications

1. Known hypersensitivity to the drug


2. Males with carcinoma of the breast


3. Males with known or suspected carcinoma of the prostate gland


4. Women who are or who may become pregnant


5. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal or hepatic disease.

Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.

This product contains benzyl alcohol. Benzyl alcohol has been reported to be associated with a fatal "Gasping Syndrome" in premature infants.

Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.

This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action.

Testosterone cypionate is not for intravenous use.

Information for patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug interactions

Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Carcinogenesis

Animal data

Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

Human data

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Pregnancy

Teratogenic Effects

Pregnancy Category X. (See CONTRAINDICATIONS.)

Nursing mothers

Depo-Testosterone is not recommended for use in nursing mothers.

Pediatric use

Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

Adverse Reactions

The following adverse reactions in the male have occurred with some androgens:

Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.

Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.

Miscellaneous: Inflammation and pain at the site of intramuscular injection.

Drug Abuse and Dependence

Controlled Substance Class

Testosterone is a controlled substance under the Anabolic Steroids Control Act, and Depo-Testosterone Injection has been assigned to Schedule III.

Overdosage

There have been no reports of acute overdosage with the androgens.

Depo-Testosterone Dosage and Administration

Depo-Testosterone Injection is for intramuscular use only.

It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle.

The suggested dosage for Depo-Testosterone Injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions.

Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.

For replacement in the hypogonadal male, 50–400 mg should be administered every two to four weeks.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.

How is Depo-Testosterone Supplied

Depo-Testosterone Injection is available as follows:

100 mg/mL

    10 mL vials                    NDC 0009-0347-02

200 mg/mL

    1 mL vials                      NDC 0009-0417-01

    10 mL vials                    NDC 0009-0417-02

Vials should be stored at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Protect from light.

Rx only

LAB-0245-2.0

September 2006

PRINCIPAL DISPLAY PANEL - 100 mg/mL Vial Carton

NDC 0009-0347-02

One 10 mL Vial

Multiple-Dose

Rx only

Depo®-

Testosterone

testosterone cypionate

injection, USP

CIII

For intramuscular use only

100 mg/mL

Pfizer

Distributed by

Pharmacia & Upjohn Co

Division of Pfizer Inc, NY, NY 10017

PRINCIPAL DISPLAY PANEL - 200 mg/mL Vial Carton

NDC 0009-0417-02

One 10 mL Vial

Multiple-Dose

Rx only

Depo®-

Testosterone

testosterone cypionate

injection, USP

CIII

For intramuscular use only

200 mg/mL

Pfizer

Distributed by

Pharmacia & Upjohn Co

Division of Pfizer Inc, NY, NY 10017

Depo-Testosterone  testosterone cypionate  injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0009-0347 Route of Administration INTRAMUSCULAR DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength testosterone cypionate (testosterone) testosterone cypionate 100 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength benzyl benzoate 0.1 mL  in 1 mL cottonseed oil 736 mg  in 1 mL benzyl alcohol 9.45 mg  in 1 mL

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0009-0347-02 10 mL In 1 VIAL None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA085635	07/25/1979

Depo-Testosterone  testosterone cypionate  injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0009-0417 Route of Administration INTRAMUSCULAR DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength testosterone cypionate (testosterone) testosterone cypionate 200 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength benzyl benzoate 0.2 mL  in 1 mL cottonseed oil 560 mg  in 1 mL benzyl alcohol 9.45 mg  in 1 mL

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0009-0417-01 1 mL In 1 VIAL None 2 0009-0417-02 10 mL In 1 VIAL None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA085635	07/25/1979

Labeler - Pharmacia and Upjohn Company (829076566)

Establishment
Name	Address	ID/FEI	Operations
Pharmacia and Upjohn Company		829076566	MANUFACTURE

Revised: 02/2010Pharmacia and Upjohn Company

More Depo-Testosterone resources

• Depo-Testosterone Side Effects (in more detail)
• Depo-Testosterone Use in Pregnancy & Breastfeeding
• Depo-Testosterone Drug Interactions
• Depo-Testosterone Support Group
• 0 Reviews for Depo-Testosterone - Add your own review/rating

• Depo-Testosterone MedFacts Consumer Leaflet (Wolters Kluwer)


• Testosterone Professional Patient Advice (Wolters Kluwer)


• Testosterone Monograph (AHFS DI)


• AndroGel Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Androderm Patch MedFacts Consumer Leaflet (Wolters Kluwer)


• Androderm Advanced Consumer (Micromedex) - Includes Dosage Information


• Androgel Advanced Consumer (Micromedex) - Includes Dosage Information


• Androgel Consumer Overview


• Axiron Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Axiron Consumer Overview


• Delatestryl MedFacts Consumer Leaflet (Wolters Kluwer)


• Fortesta Consumer Overview


• Fortesta Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Striant MedFacts Consumer Leaflet (Wolters Kluwer)


• Striant Consumer Overview


• Striant Advanced Consumer (Micromedex) - Includes Dosage Information


• Testim Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Depo-Testosterone with other medications

• Breast Cancer, Palliative
• Delayed Puberty, Male
• Hypogonadism, Male
• Postpartum Breast Pain

Flintstones with Iron Chewable

Generic Name: multivitamin with iron (MUL tee VYE ta mins with i ron)

Brand Names:

What is Flintstones with Iron Chewable (multivitamin with iron)?

Multivitamin are a combination of many different vitamins that are normally found in foods and other natural sources.

Iron is normally found in foods like red meat. In the body, iron becomes a part of your hemoglobin (HEEM o glo bin) and myoglobin (MY o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen.

Multivitamin and iron are used to provide vitamins and iron that are not taken in through the diet. They are also used to treat iron or vitamin deficiencies caused by illness, pregnancy, poor nutrition, digestive disorders, and many other conditions.

Multivitamin and iron may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Flintstones with Iron Chewable (multivitamin with iron)?

Never take more than the recommended dose of a multivitamin. Avoid taking any other multivitamin product within 2 hours before or after you take multivitamin with iron. Taking similar vitamin products together at the same time can result in a vitamin overdose or serious side effects. Seek emergency medical attention if you think you have used too much of this medicine. An overdose of vitamins A, D, E, or K can cause serious or life-threatening side effects. Iron and other minerals contained in a multivitamin can also cause serious overdose symptoms if you take too much.

Overdose symptoms may include severe stomach pain, vomiting, bloody diarrhea, coughing up blood, constipation, loss of appetite, hair loss, peeling skin, warmth or tingly feeling, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine or stools, black and tarry stools, pale skin, easy bruising or bleeding, weakness, shallow breathing, weak and rapid pulse, pale skin, blue lips, and seizure (convulsions).

Do not take this medication with milk, other dairy products, calcium supplements, or antacids that contain calcium. Calcium may make it harder for your body to absorb certain ingredients of the multivitamin with iron.

What should I discuss with my healthcare provider before taking Flintstones with Iron Chewable (multivitamin with iron)?

Iron and certain vitamins can cause serious or life-threatening side effects if taken in large doses. Do not take more of this medication than directed on the label or prescribed by your doctor.

If you have any medical conditions, ask your doctor before taking a multivitamin with iron. If you have certain conditions, you may need a certain vitamin formulation or special tests while taking this product.

Do not take multivitamin with iron without telling your doctor if you are pregnant or plan to become pregnant. Some vitamins and minerals can harm an unborn baby if taken in large doses. You may need to use a prenatal vitamin specially formulated for pregnant women. Multivitamin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Flintstones with Iron Chewable (multivitamin with iron)?

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

Never take more than the recommended dose of multivitamin with iron. Avoid taking any other multivitamin product within 2 hours before or after you take multivitamin with iron. Taking similar vitamin products together at the same time can result in a vitamin overdose or serious side effects.

Many multivitamin products also contain minerals such as calcium, magnesium, potassium, and zinc. Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. Read the label of any multivitamin product you take to make sure you are aware of what it contains.

Take your multivitamin with a full glass of water. You may take the multivitamin with food if it upsets your stomach.

The chewable tablet must be chewed or allowed to dissolve in the mouth before swallowing.

Measure the liquid form of this multivitamin using a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Liquid multivitamin may sometimes be mixed with water, fruit juice, or infant formula (but not milk or other dairy products). Follow the directions on the medicine label.

Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

It is important to take multivitamin with iron regularly to get the most benefit.

Store this medication at room temperature away from moisture and heat. Keep the liquid medicine from freezing.

Store multivitamin in their original container. Storing multivitamin in a glass container can ruin the medication.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of vitamins A, D, E, or K can cause serious or life-threatening side effects. Iron and other minerals contained in a multivitamin can also cause serious overdose symptoms.

Overdose symptoms may include severe stomach pain, vomiting, bloody diarrhea, coughing up blood, constipation, loss of appetite, hair loss, peeling skin, warmth or tingly feeling, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine or stools, black and tarry stools, pale skin, easy bruising or bleeding, weakness, shallow breathing, weak and rapid pulse, pale skin, blue lips, and seizure (convulsions).

What should I avoid while taking Flintstones with Iron Chewable (multivitamin with iron)?

Avoid taking any other multivitamin product within 2 hours before or after you take multivitamin with iron. Taking similar vitamin products together at the same time can result in a vitamin overdose or serious side effects.

Avoid the regular use of salt substitutes in your diet if your multivitamin contains potassium. If you are on a low-salt diet, ask your doctor before taking a vitamin or mineral supplement.

Avoid taking an antibiotic medicine within 2 hours before or after you take multivitamin with iron. This is especially important if you are taking an antibiotic such as ciprofloxacin (Cipro), demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), norfloxacin (Noroxin), ofloxacin (Floxin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Certain foods can also make it harder for your body to absorb iron. Avoid taking this multivitamin within 1 hour before or 2 hours after eating fish, meat, liver, and whole grain or "fortified" breads or cereals.

Do not take this medication with milk, other dairy products, calcium supplements, or antacids that contain calcium. Calcium may make it harder for your body to absorb certain ingredients of the multivitamin.

Flintstones with Iron Chewable (multivitamin with iron) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor if you have serious side effects such as:

• 
  

  bright red blood in your stools; or

  
  


• 
  

  pain in your chest or throat when swallowing a ferrous fumarate tablet.

  
  

When taken as directed, multivitamin are not expected to cause serious side effects. Less serious side effects may include:

• 
  

  constipation, diarrhea;

  
  


• 
  

  nausea, vomiting, heartburn;

  
  


• 
  

  stomach pain, upset stomach;

  
  


• 
  

  black or dark-colored stools or urine;

  
  


• 
  

  temporary staining of the teeth;

  
  


• 
  

  headache; or

  
  


• 
  

  unusual or unpleasant taste in your mouth.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Flintstones with Iron Chewable (multivitamin with iron)?

Vitamin and mineral supplements can interact with certain medications, or affect how medications work in your body. Before taking multivitamin with iron, tell your doctor if you also use:

• 
  

  acetohydroxamic acid (Lithostat);

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  deferoxamine (Desferal);

  
  


• 
  

  etidronate (Didronel);

  
  


• 
  

  diuretics (water pills);

  
  


• 
  

  heart or blood pressure medications;

  
  


• 
  

  tretinoin (Vesanoid);

  
  


• 
  

  isotretinoin (Accutane, Amnesteen, Clavaris, Sotret);

  
  


• 
  

  dimercaprol (an injection used to treat poisoning by arsenic, lead, or mercury);

  
  


• 
  

  penicillamine (Cuprimine);

  
  


• 
  

  pancrelipase (Cotazym, Creon, Ilozyme, Pancrease, Ultrase);

  
  


• 
  

  trimethoprim and sulfamethoxazole (Cotrim, Bactrim, Septra, TMP/SMX); or

  
  


• 
  

  an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.

  
  

This list is not complete and there may be other medications that can interact with or be affected by multivitamin with iron. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Flintstones with Iron Chewable resources

• Flintstones with Iron Chewable Side Effects (in more detail)
• Flintstones with Iron Chewable Use in Pregnancy & Breastfeeding
• Flintstones with Iron Chewable Drug Interactions
• 0 Reviews for Flintstones with Iron Chewable - Add your own review/rating

• Multivitamin with Iron Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Anemagen MedFacts Consumer Leaflet (Wolters Kluwer)


• BiferaRx MedFacts Consumer Leaflet (Wolters Kluwer)


• Chromagen Forte MedFacts Consumer Leaflet (Wolters Kluwer)


• Ferocon MedFacts Consumer Leaflet (Wolters Kluwer)


• Ferotrin Prescribing Information (FDA)


• Ferralet 90 Prescribing Information (FDA)


• Ferralet 90 MedFacts Consumer Leaflet (Wolters Kluwer)


• Ferrex 150 Forte Prescribing Information (FDA)


• Ferrex 150 Forte Plus Prescribing Information (FDA)


• Ferrex 150 Forte Plus MedFacts Consumer Leaflet (Wolters Kluwer)


• Ferrex 28 Prescribing Information (FDA)


• FerroGels Forte MedFacts Consumer Leaflet (Wolters Kluwer)


• FerroGels Forte Prescribing Information (FDA)


• FoliTab 500 MedFacts Consumer Leaflet (Wolters Kluwer)


• Fumatinic MedFacts Consumer Leaflet (Wolters Kluwer)


• Hematogen Forte Prescribing Information (FDA)


• Integra MedFacts Consumer Leaflet (Wolters Kluwer)


• Integra F MedFacts Consumer Leaflet (Wolters Kluwer)


• Integra F Prescribing Information (FDA)


• Integra Plus MedFacts Consumer Leaflet (Wolters Kluwer)


• Integra Plus Prescribing Information (FDA)


• Irospan 24/6 MedFacts Consumer Leaflet (Wolters Kluwer)


• Irospan 24/6 Prescribing Information (FDA)


• NovaFerrum Prescribing Information (FDA)


• NovaFerrum MedFacts Consumer Leaflet (Wolters Kluwer)


• Proferrin-Forte MedFacts Consumer Leaflet (Wolters Kluwer)


• Tricon Prescribing Information (FDA)

Compare Flintstones with Iron Chewable with other medications

• Anemia
• Vitamin/Mineral Supplementation and Deficiency

Where can I get more information?

• Your pharmacist can provide more information about multivitamin with iron.

See also: Flintstones with Iron Chewable side effects (in more detail)

Omeloxan

Omeloxan may be available in the countries listed below.

Ingredient matches for Omeloxan

Omeprazole

Omeprazole is reported as an ingredient of Omeloxan in the following countries:

• Germany

International Drug Name Search

Treagan

Pronunciation: AN-tee-PYE-reen/BEN-zoe-kane/POL-ee-COHS-an-ol
Generic Name: Antipyrine/Benzocaine/U-Polycosanol
Brand Name: Examples include Auralgan and Treagan

Treagan is used for:

Relieving pain and inflammation in the ear caused by certain ear conditions. It may be used with antibiotics given by mouth to treat certain ear infections. It may also be used to help remove a buildup of earwax.

Treagan is an astringent, analgesic, and anesthetic combination. It works by relieving pressure and reducing inflammation, congestion, pain, and discomfort.

Do NOT use Treagan if:

• you are allergic to any ingredient in Treagan or to similar medicines


• your eardrum is perforated or you have a discharge from the ear

Contact your doctor or health care provider right away if any of these apply to you.

Before using Treagan:

Some medical conditions may interact with Treagan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Treagan. However, no specific interactions with Treagan are known at this time.

Ask your health care provider if Treagan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Treagan:

Use Treagan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Treagan is for topical use in the ear canal only. Do not get Treagan in the eyes, nose, or mouth. If you get Treagan in any of these areas, rinse right away with cool water.


• Before using, hold the ear drop container in your hand for 1 or 2 minutes to avoid dizziness that may result from putting cold drops into the ear. To use ear drops, lie down or tilt your head so that the affected ear faces up. For adults, gently pull the earlobe up and back to straighten the ear canal. For children, gently pull the earlobe down and back to straighten the ear canal. Drop the medicine into the ear canal. Keep the ear facing up for several minutes so the medicine can run to the bottom of the ear canal. Moisten a clean cotton plug with Treagan and gently insert into the ear canal to prevent medicine from leaking out.


• To prevent germs from contaminating the medicine, do not touch the applicator to any surface, including the ear. Do not rinse dropper after use. Keep the container tightly closed.


• If Treagan is brown or contains particles, do not use it.


• If you miss a dose of Treagan, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Treagan.

Important safety information:

• Treagan may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Treagan while you are pregnant. It is not known if Treagan is found in breast milk. If you are or will be breast-feeding while you use Treagan, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Treagan:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with Treagan. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); irritation not present when you began using Treagan.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

See also: Treagan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Treagan:

Store Treagan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Protect from freezing. Keep the container tightly closed. Store away from heat, moisture, and light. Keep Treagan out of the reach of children and away from pets.

General information:

• If you have any questions about Treagan, please talk with your doctor, pharmacist, or other health care provider.


• Treagan is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Treagan. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Treagan resources

• Treagan Side Effects (in more detail)
• Treagan Use in Pregnancy & Breastfeeding
• Treagan Support Group
• 0 Reviews for Treagan - Add your own review/rating

• Treagan Concise Consumer Information (Cerner Multum)


• Otic Edge Prescribing Information (FDA)

Compare Treagan with other medications

• Ear Wax Impaction

Ulsen

Ulsen may be available in the countries listed below.

Ingredient matches for Ulsen

Omeprazole

Omeprazole is reported as an ingredient of Ulsen in the following countries:

• Dominican Republic


• El Salvador


• Honduras


• Mexico

International Drug Name Search

Advair Diskus Powder

Pronunciation: floo-TIK-a-sone/sal-MEE-ter-ol
Generic Name: Fluticasone/Salmeterol
Brand Name: Advair Diskus

Long-acting beta-agonists, such as one of the active ingredients in Advair Diskus Powder (salmeterol), have been rarely associated with an increased risk of asthma-related death. They may also increase the risk of asthma-related hospitalizations in CHILDREN and TEENAGERS. Advair Diskus Powder should only be used to treat asthma in patients who are not controlled by using other long-term asthma-control medicine. Advair Diskus Powder should not be used in patients whose asthma can be controlled by inhaled corticosteroids (eg, fluticasone).

Advair Diskus Powder is used for:

Treating asthma in certain patients. It may also be used for long-term treatment of chronic obstructive pulmonary disease (COPD) in certain patients. It may also be used to treat other breathing conditions as determined by your doctor.

Advair Diskus Powder is an inhaled corticosteroid and long-acting bronchodilator combination. The corticosteroid works by reducing inflammation and the bronchodilator works by widening the airways in the lungs. This helps you breathe more easily.

Do NOT use Advair Diskus Powder if:

• you are allergic to any ingredient in Advair Diskus Powder or to milk proteins


• you are having an asthma attack or severe breathing problems (eg, sudden, severe onset or worsening of asthma or COPD symptoms, such as chest tightness, cough, shortness of breath, wheezing)


• you are using another type of long-acting inhaled bronchodilator (eg, formoterol, salmeterol)


• you are taking certain azole antifungals (eg, itraconazole, ketoconazole), a macrolide antibiotic (eg, clarithromycin), nefazodone, protease inhibitors (eg, atazanavir, boceprevir, indinavir, ritonavir), or telithromycin


• you have asthma that is already well controlled with the use of a long-term asthma-control medicine (eg, inhaled corticosteroid)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Advair Diskus Powder:

Some medical conditions may interact with Advair Diskus Powder. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of diabetes, eye problems (eg, cataracts, glaucoma, increased pressure in the eye), heart problems (eg, fast or irregular heartbeat, heart blood vessel problems), high blood pressure, nervous system problems, liver problems, low blood potassium levels, high blood acid levels (eg, ketoacidosis), seizures, thyroid problems, or an adrenal gland tumor


• if you are having a COPD flare-up, have recently been to an emergency room for asthma, have a history of frequent hospitalizations for asthma, or have ever had a life-threatening asthma attack


• if you have a fungal, bacterial, or parasitic infection; a viral infection (eg, measles, chickenpox, shingles); herpes virus infection of the eye; tuberculosis (TB); a history of a positive TB skin test; an immune system problem or if you are taking a medicine to suppress the immune system (eg, tacrolimus); or if you have had a recent vaccination


• if you have weak bones (osteoporosis) or have risk factors of osteoporosis (eg, a family history of osteoporosis, tobacco use, long-term alcohol use, long-term use of corticosteroids or certain seizure medicines, limited physical exercise, poor nutrition)


• if you have had an unusual reaction to a sympathomimetic medicine (eg, albuterol, pseudoephedrine), such as fast or irregular heartbeat, overexcitement, or severe trouble sleeping


• if you are taking an oral corticosteroid (eg, prednisone) or an inhaled corticosteroid (eg, fluticasone)


• if you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or tricyclic antidepressant (eg, amitriptyline), or if you have taken either of these medicines within the last 14 days

Some MEDICINES MAY INTERACT with Advair Diskus Powder. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, hydrochlorothiazide, furosemide) or other long-acting inhaled bronchodilators (eg, salmeterol inhalation powder, formoterol inhalation powder ) because the risk of low blood potassium or irregular heartbeat may be increased


• Beta-blockers (eg, propranolol) because they may decrease Advair Diskus Powder's effectiveness


• Azole antifungals (eg, fluconazole), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), delavirdine, linezolid, macrolide antibiotics (eg, clarithromycin), MAOIs (eg, phenelzine), nefazodone, protease inhibitors (eg, atazanavir, boceprevir, indinavir, ritonavir), short-acting beta-agonist bronchodilators (eg, albuterol), telithromycin, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Advair Diskus Powder's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Advair Diskus Powder may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Advair Diskus Powder:

Use Advair Diskus Powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Advair Diskus Powder comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Advair Diskus Powder refilled.


• Always activate and use this device in a level, horizontal position. Do NOT try to use a spacer device with Advair Diskus Powder.


• Hold the device in one hand and put the thumb of your other hand on the thumb grip. Push your thumb away from you as far as it will go until the mouthpiece appears and snaps into position.


• Hold the device in a level, flat position with the mouthpiece toward you. Slide the lever away from you as far as it will go until it clicks.


• Do NOT close or tilt the device, play with the lever, or move the lever more than 1 time. This may release or waste extra doses.


• Hold the device away from your mouth and breathe out fully. Do NOT breathe into the inhaler. Put the mouthpiece to your lips. Breathe in quickly and deeply through the device.


• Remove the device from your mouth. Hold your breath for about 10 seconds, or as long as is comfortable. Then breathe out slowly.


• Close the device. Put your thumb on the thumb grip and slide it back toward you as far as it will go. The device will click shut and the lever will return to its original position.


• Your dose of medicine is a very fine powder. Most, but not all, patients can taste or feel the dose. Do NOT use another dose if you do not taste or feel the medicine. If you are not sure if you are receiving your dose, contact your doctor or pharmacist.


• Rinse your mouth with water after using Advair Diskus Powder. DO NOT swallow the rinse solution. Spit the rinse water out.


• If you are using other inhaled medicines, wait a few minutes between using Advair Diskus Powder and other inhalers, unless directed otherwise by your doctor.


• Take your doses of Advair Diskus Powder about 12 hours apart, unless your doctor tells you otherwise.


• Never wash the mouthpiece or any other part of the inhaler. Keep it dry. Store Advair Diskus Powder in a dry place.


• Throw Advair Diskus Powder away 1 month after you remove it from the foil pouch, or after the dose indicator reads "0," whichever comes first.


• You may breathe more easily after the first dose of Advair Diskus Powder. However, it may take 1 week or longer to achieve the most benefit.


• Use Advair Diskus Powder on a regular schedule to get the most benefit from it. Using Advair Diskus Powder at the same times each day will help you remember to use it. Do not stop using Advair Diskus Powder even if you feel better unless your doctor tells you to.


• If you miss a dose of Advair Diskus Powder, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Advair Diskus Powder.

Important safety information:

• Advair Diskus Powder may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Advair Diskus Powder with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Advair Diskus Powder will not stop an asthma attack once one has started. Be sure to carry a short-acting bronchodilator inhaler (eg, albuterol) with you at all times to treat any breathing problems that may occur between doses of Advair Diskus Powder (eg, severe or sudden onset of wheezing or shortness of breath). If you have any questions about which medicines stop asthma attacks, check with your doctor or pharmacist.


• If you have been regularly using a short-acting bronchodilator inhaler, talk with your doctor about how to use it with Advair Diskus Powder. Short-acting bronchodilators are normally only used with Advair Diskus Powder to treat breathing problems that may occur between doses.


• Advair Diskus Powder should be used to treat asthma only if your asthma is not well controlled while you are using a certain long-term asthma-control medicine (eg, inhaled corticosteroid) or if you have severe asthma. Contact your doctor if you have questions about this information.


• Talk with your doctor or pharmacist about all of your asthma medicines and how to use them. Your doctor may make changes to your asthma-control medicines once your asthma is well controlled. Do not start, stop, or change the dose of any asthma medicine unless your doctor tells you to.


• If your symptoms do not get better within 1 week or if they get worse after you start using Advair Diskus Powder, check with your doctor.


• Tell your doctor or dentist that you take Advair Diskus Powder before you receive any medical or dental care, emergency care, or surgery.


• Tell your doctor at once if you notice your short-acting bronchodilator inhaler does not work as well, if you need to use it more often (eg, more than 4 times a day for more than 2 days in a row, or 1 whole canister within 8 weeks' time), or if you have a decrease in your peak meter flow results.


• The risk of serious heart problems (eg, irregular heartbeat) may be greater if you use Advair Diskus Powder in high doses. Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Advair Diskus Powder may sometimes causes severe breathing problems right after you use a dose. If this happens, use your short-acting bronchodilator inhaler. Seek medical care at once if your breathing does not improve after you use the short-acting bronchodilator. Tell your doctor about this reaction.


• Use caution if you switch from an oral steroid (eg, prednisone) to Advair Diskus Powder. It may take several months for your body to make enough natural steroids to handle events that cause physical stress. Such events may include injury, surgery, infection, a sudden asthma attack, or severe fluid or electrolyte loss. These may be severe and sometimes fatal. Contact your doctor right away if any of these events occur. You may need to take an oral steroid (eg, prednisone) again. Carry a card at all times that says you may need an oral steroid (eg, prednisone) if any of these events occur.


• If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. Contact your doctor at once if you have contact with anyone who has these infections.


• Check with your doctor before you receive any vaccine while you are using Advair Diskus Powder.


• Diabetes patients - Advair Diskus Powder may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Lab tests, including lung function, bone density, and eye exams, may be performed while you use Advair Diskus Powder. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Advair Diskus Powder with caution in the ELDERLY; they may be more sensitive to its effects, especially pneumonia, decreased bone density, and effects on the heart.


• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Advair Diskus Powder.


• Advair Diskus Powder should not be used in CHILDREN younger than 4 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Advair Diskus Powder while you are pregnant. It is not known if Advair Diskus Powder is found in breast milk. If you are or will be breast-feeding while you use Advair Diskus Powder, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Advair Diskus Powder:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; mild muscle or bone pain; nausea; nervousness; throat irritation; tremor; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); behavior changes; blurred vision or other vision changes; burning, numbness, or tingling; chest pain; choking; fast or irregular heartbeat; overexcitement; seizures; severe muscle weakness, cramps, or spasms; severe or persistent bone pain; severe or persistent dizziness, headache, nervousness, or tremor; signs of infection (eg, fever, chills, cough, persistent sore throat, ear pain, increased mucus production, change in mucus color); swelling or tightness in the throat; symptoms of high blood sugar (eg, increased thirst, urination, or hunger; unusual weakness or drowsiness; confusion); trouble sleeping; unusual tiredness or weakness; vaginal odor or discharge; weight gain; white patches or sores on the tongue or mouth; worsening of asthma or COPD symptoms (eg, increased wheezing, coughing, chest tightness, shortness of breath).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Advair Diskus side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fainting; fast or irregular heartbeat; muscle cramping, pain, or weakness; seizures; severe or persistent dizziness, dry mouth, fatigue, headache, nausea, nervousness, tremor, or trouble sleeping.

Proper storage of Advair Diskus Powder:

Store Advair Diskus Powder between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Advair Diskus Powder out of the reach of children and away from pets.

General information:

• If you have any questions about Advair Diskus Powder, please talk with your doctor, pharmacist, or other health care provider.


• Advair Diskus Powder is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Advair Diskus Powder. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Advair Diskus resources

• Advair Diskus Side Effects (in more detail)
• Advair Diskus Use in Pregnancy & Breastfeeding
• Advair Diskus Drug Interactions
• Advair Diskus Support Group
• 38 Reviews for Advair Diskus - Add your own review/rating

Compare Advair Diskus with other medications

• Asthma, Maintenance
• COPD, Maintenance

Advicor

Generic Name: lovastatin and niacin (Oral route)

NYE-a-sin, loe-va-STAT-in

Commonly used brand name(s)

In the U.S.

• Advicor

Available Dosage Forms:

• Tablet


• Tablet, Extended Release

Therapeutic Class: Antihyperlipidemic

Pharmacologic Class: Vitamin B

Chemical Class: Nicotinic Acid (class)

Uses For Advicor

Niacin extended-release and Lovastatin combination medicine is used to help lower high cholesterol and fat levels in the blood. This may help prevent medical problems caused by cholesterol and fat clogging the blood vessels.

Niacin extended-release and lovastatin combination medicine combines two drugs that work together to treat cholesterol and lipid (fat) disorders. Niacin is a B-complex vitamin that reduces the amount of cholesterol in the blood. Lovastatin belongs to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. It works by blocking an enzyme that is needed by the body to make cholesterol, thereby reducing the amount of cholesterol in the blood

This medicine is available only with your doctor's prescription.

Before Using Advicor

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

This combination medicine should not be used until after your body has adjusted to each of the individual medicines. Be sure to check with your doctor about this.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of niacin extended-release and lovastatin combination in children with use in other age groups.

Geriatric

This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Atazanavir


• Boceprevir


• Clarithromycin


• Darunavir


• Fosamprenavir


• Itraconazole


• Lopinavir


• Mibefradil


• Ritonavir


• Saquinavir


• Telaprevir


• Tipranavir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Amprenavir


• Atorvastatin


• Bezafibrate


• Cerivastatin


• Ciprofibrate


• Clofibrate


• Colchicine


• Conivaptan


• Cyclosporine


• Dalfopristin


• Danazol


• Daptomycin


• Delavirdine


• Erythromycin


• Everolimus


• Fenofibrate


• Fluconazole


• Gemfibrozil


• Indinavir


• Ketoconazole


• Lovastatin


• Nefazodone


• Nelfinavir


• Niacin


• Pitavastatin


• Posaconazole


• Quinupristin


• Ranolazine


• Rosuvastatin


• Simvastatin


• Telithromycin


• Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Azithromycin


• Bosentan


• Diltiazem


• Oat Bran


• Pectin


• St John's Wort


• Voriconazole


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol


• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems or


• Diabetes mellitus (sugar diabetes) or


• Endocrine problems or


• Gout or


• Heart Disease or


• Liver disease or


• Low blood pressure or


• Stomach Ulcer—Niacin extended-release and lovastatin combination may make these conditions worse.

• Kidney Disease—Effects of niacin extended-release and lovastatin combination may be increased because of slower removal of medicine from the body.

Proper Use of Advicor

Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, particularly saturated fat, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.

Make certain your doctor knows if you are on any special diet, such as a low-sodium or low-sugar diet.

Use this medicine only as directed by your doctor. Do not use more or less of it, and do not use it more often or for a longer time than your doctor ordered. Also, this medicine works best if there is a constant amount in the blood. To help keep this amount constant, do not miss any doses and take the medicine at the same time each day.

Remember that this medicine will not cure your condition but it does help control it. Therefore, you must continue to take it as directed to keep your cholesterol levels down.

Follow carefully the special diet your doctor gave you.This is an important part of controlling your condition, and is necessary if the medicine is to work properly.

Do not drink any grapefruit juice around the time you take this medicine. It may be best to drink any grapefruit juice approximately 12 hours before or after you take your medicine. In addition, do not drink grapefruit juice in large quantities (more than one quart per day) while you are being treated with niacin extended-release and lovastatin combination. To do so may increase the risk of developing muscle problems. Check with your doctor if you have any questions.

Take this medicine at bedtime after eating a low fat snack. Swallow the tablet whole. Do not crush, break, or chew the tablet before you swallow it.

This medicine may cause you to have skin flushing which makes your face, neck, arms and occasionally, your upper chest to feel warm and look red. Flushing usually starts about two to four hours after you take your medicine, and may last up to several hours. Flushing can also cause itching and/or a tingling sensation. A more intense episode of flushing may include dizziness or faintness. If you take your medicine at bedtime, you may sleep through any flushing that occurs. If awakened by flushing, rise slowly to minimize the potential for dizziness or fainting. Avoiding alcohol or hot drinks may reduce the flushing. This effect should lessen after several weeks as your body gets used to the medicine. However, if the problem continues or gets worse, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • 
    
    • Adults—The starting dose is usually, 500 milligrams (mg) of niacin extended-release and 20 mg of lovastatin (combined in one tablet) one time a day, at bedtime with a low fat snack. Then your doctor may increase your dose a little at a time every 4 weeks, as your body gets used to the medicine, until your cholesterol is controlled.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you have not taken this medicine for more than 7 days, check with your doctor. You may need to have your dose reduced before you can start taking this medicine again.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Advicor

Check with your doctor immediately if you have dark-colored urine, a fever, muscle cramps or spasms, muscle pain or stiffness, or feel very tired or weak.Niacin extended-release and lovastatin combination may cause a serious, but rare, problem called rhabdomyolysis. It is important to call your doctor right away if you have any of these symptoms.

It is very important that your doctor check your progress at regular visits.This will allow your doctor to see if the medicine is working properly to lower your cholesterol and triglyceride (fat) levels and that it does not cause unwanted side effects. At regular intervals, your doctor will want to do routine blood tests.

For diabetic patients: This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Do not stop taking niacin extended-release and lovastatin combination without first checking with your doctor. When you stop taking this medicine, your blood cholesterol levels may increase again.

Check with your doctor immediately if you think that you may be pregnant. Niacin extended-release and lovastatin combination may cause birth defects or other problems in the baby if taken during pregnancy.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

Advicor Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Asthenia, such as, lack or loss of strength


• infection, such as, cough or hoarseness, fever or chills, lower back or side pain, painful or difficult urination


• pain

Less common

• Abdominal pain, such as, stomach pain


• hyperglycemia, such as, abdominal pain, blurred vision, dry mouth, fatigue, dry skin, fruit-like breath odor, increased hunger, increased thirst, increased urination, nausea, unexplained weight loss, vomiting


• myalgia, such as, difficulty in moving, joint pain, muscle aching, cramping pain or stiffness, swollen joints


• myopathy, such as, muscle aches, weakness, tenderness, or pain


• stomach pain

Rare

• Rhabdomyolysis, such as, dark-colored urine, fever, muscle cramps, pain, spasm, or stiffness, unusual tiredness or weakness

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

• Cardiac arrhythmia, such as, chest pain or discomfort, dizziness, fainting, fast, slow or irregular heartbeat, lightheadedness, pounding or rapid pulse


• diarrhea


• dizziness


• flushing, severe, such as, feeling of warmth, redness, itching, and/or tingling of the face, neck, arms, and occasionally, upper chest, dizziness, fainting


• hypotension, such as, blurred vision, confusion, dizziness, faintness, lightheadedness when getting up from a lying or sitting position, sudden sweating, unusual tiredness or weakness


• nausea and vomiting


• syncope, such as, fainting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

• Chills


• diarrhea


• flu syndrome, such as, chills, diarrhea, fever, general feeling of discomfort or illness, headache, joint pain, loss of appetite, muscle aches and pains, nausea, runny nose, shivering, sore throat, sweating, trouble sleeping, unusual tiredness or weakness, vomiting


• flushing, such as, feeling of warmth, redness, itching, and/or tingling of the face, neck, arms, and occasionally, upper chest


• edema, such as, swelling


• headache


• nausea


• pruritus, such as, itching skin


• rash


• shortness of breath


• sweating


• syncope, such as, feeling faint or fainting


• tachycardia, such as, fast, pounding, or irregular heartbeat or pulse

Less common

• dyspepsia, such as, acid or sour stomach, belching, heartburn, indigestion, stomach discomfort, upset or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Advicor side effects (in more detail)

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More Advicor resources

• Advicor Side Effects (in more detail)
• Advicor Use in Pregnancy & Breastfeeding
• Drug Images
• Advicor Drug Interactions
• Advicor Support Group
• 1 Review for Advicor - Add your own review/rating

• Advicor Prescribing Information (FDA)


• Advicor Concise Consumer Information (Cerner Multum)


• Advicor MedFacts Consumer Leaflet (Wolters Kluwer)

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Fluconer may be available in the countries listed below.

Ingredient matches for Fluconer

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Fluconazole is reported as an ingredient of Fluconer in the following countries:

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